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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSP90AB1 All Species: 52.12
Human Site: Y512 Identified Species: 88.21
UniProt: P08238 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08238 NP_031381.2 724 83264 Y512 K R G F E V V Y M T E P I D E
Chimpanzee Pan troglodytes A5A6K9 733 84754 Y521 K H G L E V I Y M I E P I D E
Rhesus Macaque Macaca mulatta XP_001098520 724 83571 Y512 K R G F E V V Y M T E P I D E
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P11499 724 83307 Y512 K R G F E V V Y M T E P I D E
Rat Rattus norvegicus P34058 724 83263 Y512 K R G F E V V Y M T E P I D E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518700 789 90657 Y604 K R G F E V V Y M T E P I D E
Chicken Gallus gallus Q04619 725 83409 Y513 K R G F E V V Y M T E P I D E
Frog Xenopus laevis NP_001086624 722 82939 Y510 K R G F E V V Y M T E P I D E
Zebra Danio Brachydanio rerio O57521 725 83339 Y511 K R G F E V L Y M T E P I D E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P02828 717 81847 Y505 A R G F E V V Y M T E P I D E
Honey Bee Apis mellifera XP_395168 718 82735 Y508 K R G F E V V Y M T E P I D E
Nematode Worm Caenorhab. elegans Q18688 702 80265 Y490 S R G F E V L Y M C D P I D E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P27323 700 80617 Y492 K R G Y E V L Y M V D A I D E
Baker's Yeast Sacchar. cerevisiae P02829 709 81388 F500 A K N F E V L F L T D P I D E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86 95.1 N.A. N.A. 99.1 99.5 N.A. 86.8 94.7 92.4 91.4 N.A. 78.4 81.3 75.4 N.A.
Protein Similarity: 100 93.4 96.1 N.A. N.A. 99.5 99.8 N.A. 87.5 97.7 96.6 97 N.A. 88.5 89.9 86.8 N.A.
P-Site Identity: 100 73.3 100 N.A. N.A. 100 100 N.A. 100 100 100 93.3 N.A. 93.3 100 73.3 N.A.
P-Site Similarity: 100 80 100 N.A. N.A. 100 100 N.A. 100 100 100 100 N.A. 93.3 100 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 69.6 61.4 N.A.
Protein Similarity: N.A. N.A. N.A. 83.8 78.3 N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 86.6 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 22 0 0 100 0 % D
% Glu: 0 0 0 0 100 0 0 0 0 0 79 0 0 0 100 % E
% Phe: 0 0 0 86 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 93 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 8 0 0 100 0 0 % I
% Lys: 79 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 8 0 0 29 0 8 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 93 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 93 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 86 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 79 0 0 0 0 0 % T
% Val: 0 0 0 0 0 100 65 0 0 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 93 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _